Author

R. K. Grencis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 10

Signature Assays, Organisms & Methods

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Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 10 Organism:mouse· 10 Assay:proteomics· 3 Assay:bulk RNA-seq· 2 Research Focus:cell type annotation· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:differential expression· 1

Frequent Co-Authors

D. Goulding· 3 shared D. J. Thornton· 3 shared M. Berriman· 3 shared A. J. Reid· 2 shared C. McCarthy· 2 shared K. S. Hayes· 2 shared L. Boon· 2 shared M. A. Duque-Correa· 2 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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3 shared papersImmunology

D. Goulding

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Author profile →

10 papers

Recent·Most cited

Myeloid A20 is critical for type-2 immune mediated helminth resistance

I. Petta, M. Thorp, m. Ciers, G. Blancke, L. Boon, T. Meese, F. Van Nieuwerburgh, A. Wullaert, R. K. Grencis, D. Elewaut, G. van Loo, L. Vereecke

This study identifies A20 as an essential myeloid factor for inducing type-2 immune responses against Trichuris muris, with its loss leading to chronic infection and inflammation.

bioRxiv · Sep 5, 2023 · PreprintImmunology

Mucin-degrading gut bacteria promote anti-parasitic immunity

M. Wolter, M. Boudaud, E. Grant, A. Parrish, A. De Sciscio, S. Thompson, J.-J. Gerardy, M. Mittelbronn, D. J. Thornton, A. J. Macpherson, R. K. Grencis, M. S. Desai

This study shows that mucin-degrading gut bacteria influence anti-parasitic immunity by modulating host immune responses, with dietary fiber affecting this interaction.

bioRxiv · Feb 28, 2022 · PreprintImmunology

Rhythmicity of Intestinal IgA Responses Confers Oscillatory Commensal Microbiota Mutualism

H. A. Penny, R. G. Domingues, M. Z. Krauss, F. Melo-Gonzalez, S. Dickson, J. Parkinson, M. Hurry, C. Purse, E. Jegham, C. Godinho-Silva, M. Rendas, H. Veiga-Fernandes, D. Bechtold, R. K. Grencis, K.-M. Toellner, , M. R. Hepworth

This study shows diurnal rhythms in intestinal IgA regulate oscillations in commensal microbiota abundance, promoting mutualism.

bioRxiv · Oct 11, 2021Immunology

Sustained post-developmental T-bet expression is critical for the maintenance of type 1 innate lymphoid cells in vivo

J.-H. Schroeder, L. B. Roberts, K. Meissl, J. W. Lo, D. Hromadova, K. Hayes, T. Zabinski, E. Read, C. Moreira Heliodoro, R. Reis, J. K. Howard, R. K. Grencis, J. F. Neves, B. Strobl, G. M. Lord

This study shows that sustained T-bet expression is necessary for maintaining intestinal ILC1 in vivo, and ILC1 depletion protects against colitis, suggesting potential therapeutic targeting of T-bet for IBD treatment.

bioRxiv · Jun 5, 2021Immunology

Large Neutral Amino acid uptake and mTOR activation within CD4+ T cells coordinate Type 2 immunity and host resistance to Trichuris muris

M. Z. Krauss, K. S. Hayes, A. Villegas-Mendez, M. R. Hepworth, L. V. Sinclair, K. N. Couper, R. K. Grencis

This study shows that SLC7A5-mediated mTOR activation in CD4+ T cells is essential for effective Type 2 immunity and resistance to T. muris infection.

bioRxiv · Nov 30, 2020Immunology

Defining the early stages of intestinal colonisation by whipworms

M. A. Duque Correa, D. Goulding, F. Rodgers, C. Cormie, K. A. Rawlinson, A. Gillis, A. J. Bancroft, H. M. Bennett, M. Lotkowska, A. J. Reid, A. O. Speak, P. Scott, N. Redshaw, C. McCarthy, C. Brandt, , M. Berriman

This study investigates whipworm invasion of the intestinal epithelium using mouse models and single-cell RNA sequencing, revealing host-parasite interactions and immune responses.

bioRxiv · Aug 21, 2020Immunology

Development of caecaloids to study host-pathogen interactions: new insights into immunoregulatory functions of Trichuris muris extracellular vesicles in the caecum

M. A. Duque-Correa, F. Schreiber, F. H. Rodgers, D. Goulding, S. Forrest, R. White, A. Buck, R. K. Grencis, M. Berriman

This paper develops a caecal organoid model to study host-pathogen interactions, revealing immunoregulatory effects of Trichuris muris extracellular vesicles on caecal epithelium.

bioRxiv · May 11, 2020Immunology

IL-17A both initiates (via IFNγ suppression) and limits the pulmonary type 2 immune response to nematode infection

J. Ajendra, A. L. Chenery, J. E. Parkinson, B. H. Chan, S. Pearson, S. A. Colombo, L. Boon, R. K. Grencis, T. E. Sutherland, J. E. Allen

This study shows IL-17A suppresses IFNγ to initiate and later limits type-2 immune responses in the lung during nematode infection.

bioRxiv · Apr 18, 2020Immunology

Trickle infection and immunity to Trichuris muris

M. Glover, S. A. P. Colombo, D. J. Thornton, R. K. Grencis

This study shows that repeated low-dose infection with Trichuris muris leads to gradual immunity, with CD4+ T cells playing a key role, and alters gut microbiota.

PLOS Pathogens · Nov 15, 2019Peer-reviewedImmunology

Exclusive dependence of IL-10Rα signalling on intestinal microbiota homeostasis and control of whipworm infection

M. A. Duque-Correa, N. A. Karp, C. McCarthy, S. Forman, D. Goulding, G. Sankaranarayanan, T. P. Jenkins, A. J. Reid, H. P. Browne, E. L. Cambridge, C. Ballesteros Reviriego, W. Müller, C. Cantacessi, G. Dougan, R. K. Grencis, , The 3i consortium

This study shows that IL-10R signaling in immune cells is essential for controlling whipworm infection, microbiota homeostasis, and preventing immunopathology in mice.

bioRxiv · Aug 8, 2018Immunology