Discovery of small-molecule inhibitors targeting the ribosomal peptidyl transferase center (PTC) of M. tuberculosis
B. Tam, D. Sherf, S. Cohen, S. A. Eisdorfer, M. Perez, A. Soffer, D. Vilenchik, S. R. Akabayov, G. Wagner, B. Akabayov
The paper identifies small-molecule inhibitors targeting the ribosomal peptidyl transferase center of M. tuberculosis using NMR and machine learning, showing improved potency over standard antibiotics.
bioRxiv · Aug 11, 2019Biochemistry