G. Wagner

Computational inference of eIF4F complex function and structure in human cancers

This study investigates eIF4F complex function and structure in human cancers, finding frequent gene amplifications and revealing structural mechanisms for cap-dependent and cap-independent translation initiation.

Malignant tumors engender and employ cancer-specific organelles for self-protection and metastasis

This study identifies cytocapsular oncocells and their networks as key structures driving cancer progression and metastasis through membrane-enclosed systems.

Cytocapsular cancer evolution analyses of 311 kinds of cancers

This study maps cytocapsular cancer evolution across 311 cancer types, revealing shared and distinct evolutionary processes in solid and liquid cancers.

Evolutionary Adaptations of IRG1 Refines Itaconate Synthesis and Mitigates Innate Immunometabolism Trade-offs

This study investigates the evolutionary adaptations of IRG1 to refine itaconate synthesis and mitigate trade-offs in innate immunometabolism.

Normalizing need not be the norm: count-based math for analyzing single-cell data

This paper proposes an alternative to normalization in scRNA-seq by using a restricted algebra to preserve count data, enabling meaningful comparisons without distorting results.

Cytocapsulae and cytocapsular tubes are golden targets for precise, effective and efficient cancer diagnosis and therapy in 307 kinds of liquid and solid cancers

The paper investigates the structural compartments of cancer cells and tumors in 307 cancers using clinical specimens and IHC images, identifying cytocapsular tubes and their role in cancer evolution.

Cytocapsular tube network-tumor system is an integrated physical target for the highly effective and efficient pharmacotherapy of solid cancers

This study shows that conventional tumor models do not form CCT networks, explaining poor drug efficacy, and suggests using CCT xenografts for better drug development.

Cytocapsular tubes and networks function as physical superdefence freeway systems conducting conventional cancer drug pan-resistant tumor metastasis

This study identifies cytocapsular tubes (CCTs) as physical barriers enhancing cancer drug resistance and metastasis, and develops a CCT xenograft platform for drug development.

Cancer Metastases of 202 Kinds of Cancers via Cytocapsular Tubes

The paper identifies cytocapsular tubes as a physical pathway for cancer metastasis, showing their presence in all cancer and metastatic tissues but not in normal or benign tissues.

A nascent polypeptide sequence modulates DnaA translation elongation in response to nutrient availability

The paper identifies a nascent polypeptide sequence in Caulobacter crescentus that modulates DnaA translation elongation in response to carbon availability.

Decidual cell differentiation is evolutionarily derived from fibroblast activation

The paper investigates the evolutionary origin of decidual cells by comparing mesenchymal-epithelial transition and fibroblast activation models, finding support for the latter through transcriptomic analysis.

Hidden limbs in the limbless skink Brachymeles lukbani: developmental observations

This study describes the developmental stages of limb reduction in Brachymeles lukbani, revealing hidden limb structures in adult morphologically limbless skinks.

Deep computational analysis of human cancer and non-cancer tissues details dysregulation of eIF4F components and their interactions in human cancers

The paper analyzes human cancer and non-cancer tissues to identify dysregulation of eIF4F components and their interactions, finding EIF4G1 overexpression and its association with poor prognosis.

Cis-Regulatory Differences Explaining Evolved Levels of Endometrial Invasibility in Eutherian Mammals

The paper identifies cis-regulatory differences in genomic sequences that explain species-specific variations in endometrial invasibility and their link to gene expression and stromal properties.

Human vulnerability to cancer malignancy is enhanced by evolution of higher mesenchymal CD44 expression compared to other mammals

This study shows that increased CD44 expression in human skin and endometrial stromal fibroblasts, compared to other mammals, correlates with higher cancer vulnerability.

Structural basis of the dynamic human CEACAM1 monomer-dimer equilibrium

This study identifies key residues and structural dynamics governing the monomer-dimer equilibrium of hCEACAM1 using biophysical and structural methods.

Cooption of polyalanine tract into a repressor domain in the mammalian transcription factor HoxA11

The paper shows that a polyalanine tract in HoxA11 evolved into a repressor domain in mammals, suggesting polyalanine tracts can function as repressor domains and contribute to transcription factor diversification.

Discovery of small-molecule inhibitors targeting the ribosomal peptidyl transferase center (PTC) of M. tuberculosis

The paper identifies small-molecule inhibitors targeting the ribosomal peptidyl transferase center of M. tuberculosis using NMR and machine learning, showing improved potency over standard antibiotics.

A nanobody that recognizes a 14-residue peptide epitope in the E2 ubiquitin-conjugating enzyme UBC6e modulates its activity

The paper identifies a nanobody that binds to a 14-residue epitope on UBC6e, enhancing its enzymatic activity and inhibiting phosphorylation in response to cell stress.

Evidence against tetrapod-wide digit identities and for a limited frame shift in bird wings

The paper challenges the conservation of digit identities across tetrapods and suggests a limited frame shift in bird wings based on gene expression patterns.

Pervasive correlated evolution in gene expression shapes cell type transcriptomes

This study develops a model to measure correlated transcriptome evolution across tissues and finds that related tissues show higher levels of correlated gene expression evolution.