Author

S. A. Leyn

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2

Signature Assays, Organisms & Methods

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Organism:Arabidopsis· 2 Research Focus:drug response / drug discovery· 2 Organism:E. coli· 2 Approach:experimental assay· 2 Assay:whole-genome sequencing· 2

Frequent Co-Authors

A. L. Osterman· 2 shared J. E. Zlamal· 2 shared M. Elane· 2 shared M. Vercruysse· 2 shared F. Garcia-Alcalde· 1 shared J. E. Kent· 1 shared J. W. Wamsley· 1 shared M. Iyer· 1 shared

Activity by Year

2021-2023 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 32 mutual co-author links

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2 shared papersMicrobiology

A. L. Osterman

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2 papers

Recent·Most cited

Two Classes of DNA Gyrase Inhibitors Elicit Distinct Evolutionary Trajectories Toward Resistance in Gram-Negative Pathogens

S. A. Leyn, J. E. Kent, J. E. Zlamal, M. Elane, M. Vercruysse, A. L. Osterman

This study uses experimental evolution and whole genome sequencing to compare resistance mechanisms to GP6 and ciprofloxacin in E. coli and A. baumannii, finding distinct evolutionary trajectories dominated by efflux pump upregulation for GP6.

bioRxiv · Jun 26, 2023 · PreprintMicrobiology

Shared and Unique Evolutionary Trajectories to Ciprofloxacin Resistance in Gram-negative Bacterial Pathogens

J. E. Zlamal, S. A. Leyn, M. Iyer, M. Elane, N. A. Wong, J. W. Wamsley, M. Vercruysse, F. Garcia-Alcalde, A. L. Osterman

This study uses a comparative resistomics approach to analyze the evolutionary trajectories of ciprofloxacin resistance in three Gram-negative bacteria, revealing shared and species-specific resistance mechanisms.

bioRxiv · Apr 6, 2021Microbiology