Structural basis for the simultaneous recognition of NEMO and acceptor ubiquitin by the HOIP NZF1 domain
S. Rahighi, M. Iyer, H. Oveisi, S. Nasser, V. Duong
The paper reports the crystal structure of NEMO bound to HOIP NZF1 and linear diubiquitin chains, revealing how NZF1 interacts with both NEMO and ubiquitin to facilitate site-specific ubiquitination.
bioRxiv · Feb 25, 2022Biochemistry