Molecular determinants of chaperone interactions on MHC-I for folding and antigen repertoire selection
A. C. McShan, C. A. Devlin, S. A. Overall, J. Park, J. S. Toor, D. Moschidi, D. Flores-Solis, H. Choi, S. Tripathi, E. Procko, N. G. Sgourakis
This paper identifies molecular determinants of TAPBPR chaperone interactions with MHC-I molecules, showing that conformational dynamics and disulfide bonds influence recognition and antigen repertoire selection.
bioRxiv · Sep 24, 2019Immunology