J. M. Maris

Atomically accurate de novo design of antibodies with RFdiffusion

This paper designs antibodies de novo with atomic precision using RFdiffusion and yeast display, validated by cryo-EM and biophysical methods.

A proteogenomic surfaceome study identifies DLK1 as an immunotherapeutic target in neuroblastoma

This study identifies DLK1 as a potential immunotherapeutic target in neuroblastoma through integrative proteomic, transcriptomic, and epigenomic analysis.

Advancing childhood cancer research through young investigator and advocate collaboration

This paper describes a collaborative model between young investigators and cancer advocates to enhance pediatric cancer research through improved communication and team science.

Structural principles of peptide-centric Chimeric Antigen Receptor recognition guide therapeutic expansion

This paper determines the structure of a peptide-centric Chimeric Antigen Receptor (PC-CAR) complex and identifies structural principles for antigen recognition across multiple HLA allotypes.

Polyclonal lymphoid expansion drives paraneoplastic autoimmunity in neuroblastoma

The paper investigates OMAS in neuroblastoma, finding polyclonal B- and T-cell infiltration and TLS enrichment, linking them to autoimmune and anti-tumor responses.

Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors

This study develops mRNA chimeric antigen receptor T cells targeting GPC2 on pediatric brain tumors, showing significant tumor regression and prolonged survival without toxicity.

Epigenetic state determines inflammatory sensing in neuroblastoma

The paper shows that epigenetic states in neuroblastoma cells determine their response to inflammatory stimuli, with mesenchymal states being more responsive than adrenergic states.

Integrative genomics identifies lncRNA regulatory networks across 1,044 pediatric leukemias and extra-cranial solid tumors

The paper identifies lncRNA regulatory networks in pediatric cancers using integrated genomics data from 1,044 samples, revealing their roles in proliferation, metabolism, and DNA damage.

Epigenetic regulator BMI1 promotes fusion-positive rhabdomyosarcoma proliferation and constitutes a novel therapeutic target

This study shows BMI1 promotes FP-RMS proliferation and its inhibition reduces tumor growth and activates the Hippo pathway.

A SARS-CoV-2 Vaccination Strategy Focused on Population-Scale Immunity

This paper proposes a SARS-CoV-2 vaccination strategy targeting conserved viral regions and MHC-presented epitopes to induce broad immunity.

LIN28B-PDZ Binding Kinase Signaling Promotes Neuroblastoma Metastasis

This study identifies LIN28B's role in promoting neuroblastoma metastasis through the regulation of PBK, a kinase that enhances self-renewal and migration.

High Throughput pMHC-I Tetramer Library Production Using Chaperone Mediated Peptide Exchange

The paper introduces a method to produce pMHC-I tetramer libraries using TAPBPR chaperone-mediated peptide exchange, enabling high-throughput analysis of TCR repertoires and pMHC-I specificities.