S. Nguyen

Proteomic characterization of neuronal extracellular vesicle interactomes in Alzheimer's disease mouse model through TurboID-based proximity labeling

The paper characterizes neuronal extracellular vesicle interactomes in Alzheimer's disease mouse models using TurboID-based proximity labeling and identifies disease-associated proteins.

Computationally restoring the potency of a clinical antibody against SARS-CoV-2 Omicron subvariants

This paper computationally redesigns an antibody to restore potency against SARS-CoV-2 Omicron subvariants while maintaining efficacy against Delta and other variants.

Nuclear speckles regulate HIF-2α programs and correlate with patient survival in kidney cancer

This study shows nuclear speckles vary in cancer, correlate with survival in kidney cancer, and are regulated by HIF-2 through speckle targeting motifs.

Self-Assembly of a Repeatable DNA Nanohinge System Supporting Higher Order Structure Formation

This paper introduces a repeatable DNA nanohinge system that improves scalability and functionality for higher order structure formation in DNA nanostructures.

Effect of Nivolumab therapy on Metastatic Lung Cancer in Human Microbiome

This study examines how nivolumab therapy affects the gut microbiome in lung cancer patients, finding a significant reduction in Megasphaera elsdenii levels.

Static Stability and Swim Bladder Volume in the Bluegill Sunfish (Lepomis macrochirus)

This study measures the center of mass and buoyancy in bluegill sunfish to assess how swim bladder volume affects static stability, finding no correlation between swim bladder size and stability but a significant effect of orientation.

Profound phenotypic and epigenetic heterogeneity of the HIV-1 infected CD4+ T cell reservoir

This study identifies phenotypic and epigenetic heterogeneity in the HIV-1 infected CD4+ T cell reservoir using single-cell multiomic profiling of ART-treated individuals.

HIV-specific CD8+ T-cells in tonsils express exhaustive TRM-like signatures

The paper examines HIV-specific CD8+ T-cells in tonsils, finding they exhibit TRM-like exhaustion signatures compared to blood, with differences in natural HIV controllers.

A study of the correlation between phenotypic antimicrobial susceptibility testing methods and the associated genotypes determined by whole genome sequencing for a collection of Escherichia coli of bovine origin

This study correlates whole genome sequencing with antimicrobial susceptibility testing in bovine Escherichia coli, finding strong agreement for some antibiotics but suggesting MIC measurements may be needed for intermediate resistance cases.

Mesenchymal Stromal Cell Delivery via an Ex Vivo Bioreactor Preclinical Test System Attenuates Clot Formation for Intravascular Application

This study shows that using a bioreactor to isolate mesenchymal stromal cells (MSCs) delays clot formation compared to free MSCs, suggesting improved safety for systemic administration.

Analysis of the oxidative stress regulon identifies soxS as a genetic target for resistance reversal in multi-drug resistant Klebsiella pneumoniae

This study identifies soxS as a genetic target for reversing multi-drug resistance in K. pneumoniae by analyzing its oxidative stress regulon and demonstrating its role in efflux pump regulation and tetracycline susceptibility.

The identity of human tissue-emigrant CD8+ T cells

The paper characterizes tissue-emigrant CD8+ T cells in humans and non-human primates, revealing distinct migratory behaviors and clonal dynamics.

Analysis of the mutation dynamics of SARS-CoV-2 reveals the spread history and emergence of RBD mutant with lower ACE2 binding affinity

The paper analyzes SARS-CoV-2 mutation dynamics, showing lower mutation rates than SARS and identifying an ACE2-binding affinity-reducing RBD mutation from an Indian sample collected in January 2020.

Expansions of adaptive-like NK cells with a tissue-resident phenotype in human lung and blood

The paper identifies tissue-resident adaptive-like NK cells in human lung and blood that are distinct from peripheral blood NK cells and may be useful for solid tumor therapies.

Cohesin promotes stochastic domain intermingling to ensure proper regulation of boundary-proximal genes

This study quantifies inter-TAD interactions in human cells and shows cohesin depletion reduces both intra- and inter-domain interactions, affecting gene expression near boundaries.

Multiple conformations facilitate PilT function in the type IV pilus

The paper determines four X-ray structures of PilT in different conformations and validates their physiological importance through co-evolution analysis and functional studies.

High Throughput pMHC-I Tetramer Library Production Using Chaperone Mediated Peptide Exchange

The paper introduces a method to produce pMHC-I tetramer libraries using TAPBPR chaperone-mediated peptide exchange, enabling high-throughput analysis of TCR repertoires and pMHC-I specificities.

Oncogenic Notch promotes long-range regulatory interactions within hyperconnected 3D cliques

Recurrent losses and rapid evolution of the condensin II complex in insects

The paper investigates the evolution of condensin II complex subunits in insects, finding recurrent losses and positive selection across species.

Non-antibiotic antimicrobial triclosan induces multiple antibiotic resistance through genetic mutation

This study shows that triclosan exposure induces antibiotic resistance in E. coli through genetic mutations and gene expression changes.