Author

S. A. Wisner

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Biology Disciplines

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Biochemistry· 1

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Approach:experimental assay· 1 Organism:human· 1 Assay:proteomics· 1 Approach:wet-lab / biochemical assay· 1

Frequent Co-Authors

H. Jing· 1 shared H. Lin· 1 shared M. E. Linder· 1 shared N. A. Spiegelman· 1 shared X. Chen· 1 shared X. Zhang· 1 shared

Activity by Year

2017-2017 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperBiochemistry

H. Jing

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1 paper

Recent·Most cited

SIRT2 and lysine fatty acylation regulate the oncogenic activity of K-Ras4a

H. Jing, X. Zhang, S. A. Wisner, X. Chen, N. A. Spiegelman, M. E. Linder, H. Lin

This study identifies lysine fatty acylation as a regulatory mechanism for K-Ras4a, showing that SIRT2-mediated defatty-acylation promotes oncogenic activity by enhancing endomembrane localization and interaction with A-Raf.

bioRxiv · Oct 15, 2017Biochemistry