Down syndrome fibroblasts exhibit diminished autophagic clearance and endosomal dysfunction after serum starvation
S. Aivazidis, A. Jain, C. C. Anderson, D. J. Orlicky, A. K. Rauniyar, K. S. Fritz, P. S. Harris, D. Siegel, K. N. Maclean, J. Roede
This study shows that Down syndrome fibroblasts have impaired autophagic clearance and endosomal dysfunction after serum starvation, suggesting these as potential early pathogenic mechanisms.
bioRxiv · Oct 5, 2018 · PreprintCell Biology