D. Siegel

Beneficial metabolic effects of PAHSAs depend on the gut microbiota in diet-induced obese mice

This study shows that PAHSAs improve insulin sensitivity in diet-induced obese mice via the gut microbiota, with sex-specific effects observed.

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway

This study identifies imidazolopiperazines as targeting the Plasmodium falciparum secretory pathway by inhibiting protein trafficking and ER expansion.

Chemical Impacts of the Microbiome Across Scales Reveal Novel Conjugated Bile Acids

The paper identifies novel conjugated bile acids produced by the microbiome in mice and humans using mass spectrometry and a murine 3D model.

Down syndrome fibroblasts exhibit diminished autophagic clearance and endosomal dysfunction after serum starvation

This study shows that Down syndrome fibroblasts have impaired autophagic clearance and endosomal dysfunction after serum starvation, suggesting these as potential early pathogenic mechanisms.

Saccharomyces cerevisiae goes through distinct metabolic phases during its replicative lifespan

This study describes metabolic changes in Saccharomyces cerevisiae during its replicative lifespan, showing shifts in metabolism and increased redox cofactor turnover with age.