mTOR repression in response to amino acid starvation promotes ECM degradation through MT1-MMP endocytosis arrest
C. Colombero, D. Remy, S. Antoine, A.-S. Mace, P. Monteiro, N. ElKhatib, M. Fournier, A. Dahmani, E. Montaudon, G. Montagnac, E. Marangoni, P. Chavrier
The paper shows that mTOR repression during amino acid starvation leads to increased ECM degradation via MT1-MMP endocytosis arrest in tumor cells.
bioRxiv · Jan 29, 2021Cancer Biology