Loss of nephronophthisis-associated nephrocystin-1 impairs DNA damage repair in kidney organoids
Elena Sendino Garví, S. Biermans, Nine V.A.M. Knoers, Albertien M. van Eerde, Rosalinde Masereeuw, Manoe Jacoba Janssen, Gisela G.G. Slaats, Anne Metje van Genderen
This study shows that loss of nephrocystin-1 in kidney organoids impairs DNA repair, increases senescence, and leads to fibrosis, revealing a new role for NPHP1 in DNA damage response.
bioRxiv · Jun 9, 2025 · PreprintMolecular Biology