Gentamicin impairs nephron development in iPSC-derived kidney organoids and disrupts proximal tubular lysosomal function
Elena Sendino Garví, Wiktoria Pioruńska, Lisa Böhl…·Anne Metje van Genderen
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Utrecht UniversityORCID 0000-0002-1560-1074Unclaimed ORCID profile · follow to get notified of new preprints
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6 papers
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Elena Sendino Garví, Wiktoria Pioruńska, Lisa Böhl…·Anne Metje van Genderen
Robine Janssen, Alinda J. Berends, Marit Zuurveld…·Linette E. M. Willemsen
This paper introduces an ex vivo assay to study how peanut extracts and novel foods modulate type 2 inflammation in peanut-allergic patients.
Elena Sendino Garví, S. Biermans, Nine V.A.M. Knoers…·Anne Metje van Genderen
This study shows that loss of nephrocystin-1 in kidney organoids impairs DNA repair, increases senescence, and leads to fibrosis, revealing a new role for NPHP1 in DNA damage response.
Laura Giordano, Sabbir Ahmed, Thomas K. van der Made…·Silvia Maria Mihaila
This study shows that short chain fatty acids (SCFAs) enhance kidney proximal tubule cell secretory function by upregulating OAT1 and modulating cAMP signaling pathways.
Adam Myszczyszyn, Anna Muench, Vivian Lehmann…·Bart Spee
This paper develops a liver organoid-on-a-chip model using hollow fiber membranes to study drug metabolism and transport, showing improved hepatocyte-like maturation and functional drug processing.
Judith Regina Homberg, Peter Karel, Francisca Meyer…·Michel M. M. Verheij
This study shows cocaine increases extracellular dopamine and serotonin by depleting storage vesicles in the rat nucleus accumbens, with individual differences in vesicular release affecting behavior and drug intake.