Author

Manoe Jacoba Janssen

Utrecht UniversityORCID 0000-0002-0544-8096Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Assay:multiome· 1 Assay:spatial transcriptomics· 1 Organism:zebrafish· 1

Frequent Co-Authors

Elena Sendino GarvíiD· 2 shared Albertien M. van EerdeiD· 1 shared Anne Metje van GendereniD· 1 shared Bianca Maria GoffredoiD· 1 shared Elena N. LevtchenkoiD· 1 shared Fanny Oliveira ArcolinoiD· 1 shared Florian SiegeristiD· 1 shared Gisela G.G. SlaatsiD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersMolecular Biology

Elena Sendino GarvíORCID

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2 papers

Recent·Most cited

Loss of nephronophthisis-associated nephrocystin-1 impairs DNA damage repair in kidney organoids

Elena Sendino Garví, S. Biermans, Nine V.A.M. Knoers, Albertien M. van Eerde, Rosalinde Masereeuw, Manoe Jacoba Janssen, Gisela G.G. Slaats, Anne Metje van Genderen

This study shows that loss of nephrocystin-1 in kidney organoids impairs DNA repair, increases senescence, and leads to fibrosis, revealing a new role for NPHP1 in DNA damage response.

bioRxiv · Jun 9, 2025 · PreprintMolecular Biology

CTNS mRNA as a potential treatment for nephropathic cystinosis

Tjessa Bondue, Sante Princiero Berlingerio, Florian Siegerist, Elena Sendino Garví, Maximilian Schindler, Hans J. Baelde, Sara Cairoli, Bianca Maria Goffredo, Fanny Oliveira Arcolino, Jürgen W. C. Dieker, Manoe Jacoba Janssen, Nicole Endlich, Roland E. Brock, Rik Gijsbers, Lambertus P. van den Heuvel, Elena N. Levtchenko

This paper demonstrates that synthetic CTNS mRNA therapy can restore cystinosin function and reduce cystine accumulation in kidney cells and zebrafish models of cystinosis.

Scientific Reports · Nov 28, 2023Peer-reviewedGenetics