Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97
S. Bothe, P. Haenzelmann, S. Boehler, J. Kehrein, C. Wiedemann, U. Hellmich, R. Brenk, H. Schindelin, C. Sotriffer
The paper uses biolayer interferometry to identify small molecule ligands targeting the SHP-motif binding site of p97, leading to the first structure of a small molecule complex with the N-domain of p97.
bioRxiv · Jun 1, 2022Biochemistry