C. Wiedemann

Strategic acyl carrier protein engineering enables functional type II polyketide synthase reconstitution in vitro

This study enables functional reconstitution of type II PKS in vitro by engineering acyl carrier proteins to be activatable by Sfp.

Legionella pneumophila macrophage infectivity potentiator protein appendage domains modulate protein dynamics and inhibitor binding

This study investigates the structural and functional roles of appendage domains in Legionella pneumophila MIP proteins, revealing their impact on inhibitor binding and dynamics, and provides structural insights for developing pathogen-specific inhibitors.

Crosstalk between regulatory elements in the disordered TRPV4 N-terminus modulateslipid-dependent channel activity

The paper investigates how disordered regions in TRPV4 modulate channel activity through lipid-dependent interactions and identifies a conserved autoinhibitory patch that regulates PIP2 binding.

Fragment screening using biolayer interferometry reveals ligands targeting the SHP-motif binding site of the AAA+ ATPase p97

The paper uses biolayer interferometry to identify small molecule ligands targeting the SHP-motif binding site of p97, leading to the first structure of a small molecule complex with the N-domain of p97.

Interaction of septin 7 and DOCK8 in equine lymphocytes reveals novel insights into signaling pathways associated with autoimmunity

The paper identifies DOCK8 as an interaction partner of septin 7 in equine lymphocytes and links altered DOCK8 expression and interactions to autoimmune disease mechanisms.