Author

S. C. Durley

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Cancer Biology· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

H. B. Landsverk· 1 shared L. van Bijsterveldt· 1 shared R. G. Syljuasen· 1 shared S. Sarkar· 1 shared T. C. Humphrey· 1 shared V. Näshe· 1 shared

Activity by Year

2021-2021 · peak 1/yr

Co-Author Collaboration Network

6 top collaborators · 15 mutual co-author links

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1 shared paperCancer Biology

H. B. Landsverk

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1 paper

Recent·Most cited

R-loop-induced p21 expression following CDC73, CTR9, and PAF1 loss protects cancer cells against replicative catastrophe following WEE1 inhibition

L. van Bijsterveldt, H. B. Landsverk, V. Näshe, S. C. Durley, S. Sarkar, R. G. Syljuasen, T. C. Humphrey

This study identifies PAF1 complex members and p21 as key regulators of WEE1 inhibitor sensitivity, revealing their role in protecting cancer cells from replicative catastrophe through R-loop formation and DNA damage response.

bioRxiv · Jul 14, 2021 · PreprintCancer Biology