Author

T. C. Humphrey

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:statistical model· 1

Frequent Co-Authors

S. Sarkar· 2 shared C. Cooper· 1 shared C. Toffanin· 1 shared D. Ebner· 1 shared E. Seraia· 1 shared F. A. Okonjo· 1 shared F. Buffa· 1 shared G. D. D. Jones· 1 shared

Activity by Year

2021-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCancer Biology

S. Sarkar

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Author profile →

2 papers

Recent·Most cited

R-loop-induced p21 expression following CDC73, CTR9, and PAF1 loss protects cancer cells against replicative catastrophe following WEE1 inhibition

L. van Bijsterveldt, H. B. Landsverk, V. Näshe, S. C. Durley, S. Sarkar, R. G. Syljuasen, T. C. Humphrey

This study identifies PAF1 complex members and p21 as key regulators of WEE1 inhibitor sensitivity, revealing their role in protecting cancer cells from replicative catastrophe through R-loop formation and DNA damage response.

bioRxiv · Jul 14, 2021 · PreprintCancer Biology

Therapeutic targeting of SETD2-deficient cancer cells with the small-molecule compound RITA

K. A. Lopez, S. Sarkar, E. Seraia, C. Toffanin, C. Cooper, M. Challoumas, F. A. Okonjo, G. D. D. Jones, F. Buffa, D. Ebner, T. C. Humphrey

This paper identifies RITA as a compound that selectively kills SETD2-deficient cancer cells by inducing p53-mediated apoptosis and replication stress.

bioRxiv · Jul 8, 2021 · PreprintCell Biology