Lipid membranes from naked mole-rat brain lipids are cholesterol-rich, highly phase-separated, and sensitive to amyloid-induced damage
D. FRANKEL, E. St John Smith, K. Rankin, N. Cenac, M. Davies, J. R. Kumita, M. Vendruscolo, Y. Kulaberoglu, P. Urriola Munoz, J. Bertrand-michel, M. R. Pergande, S. Preet, T. Park, A. Smith, B. Bhushan, S. Cologna
This study examines lipid composition and amyloid beta interactions in naked mole-rat brain membranes, finding they are cholesterol-rich, highly phase-separated, and more susceptible to amyloid-induced damage compared to mouse membranes.
bioRxiv · Jun 5, 2020 · PreprintBiophysics