T. Park

Thetis cells induce food-specific Treg cell differentiation and oral tolerance

This study identifies Thetis cells IV as essential for food-specific Treg cell differentiation and oral tolerance, highlighting their distinct role from dendritic cells in immune regulation.

Reconciling the spectrum of RORγt+ antigen-presenting cells

The paper reanalyzes single-cell RNA-seq data from three studies to reconcile discrepancies in identifying RORγt+ antigen-presenting cells and their role in pTreg induction.

An autochthonous model of lung cancer in the Naked Mole-Rat (Heterocephalus glaber)

This study develops an endogenous lung cancer model in naked mole-rats, showing tumor initiation more closely resembles human tumors than in mice.

Metabolic influence of core ciliates within the rumen microbiome

The paper investigates the metabolic roles of core ciliates in the rumen microbiome, finding that they contribute significantly to volatile fatty acid production and hydrogen metabolism, particularly in high methane-emitting animals.

Tumour mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade

This study shows that mitochondrial DNA mutations in complex I genes drive aerobic glycolysis, enhancing immune checkpoint blockade response in tumors.

A Multimodal Atlas of Tumor Metabolism Reveals the Architecture of Gene-Metabolite Co-regulation

The paper constructs a multimodal tumor metabolism atlas to identify gene-metabolite co-regulation patterns across cancer types.

Turbulent adaptive landscape shaped size evolution in modern ocean giants

This study analyzes the adaptive landscape of cetacean body size over 53 million years, showing a relatively flat global landscape with local peaks linked to specific adaptations.

Microscope-Cockpit: Python-based bespoke microscopy for bio-medical science

The paper introduces Microscope-Cockpit, a Python-based GUI for controlling bespoke microscopes, enabling efficient specimen navigation and hardware integration through open-source tools.

Lipid membranes from naked mole-rat brain lipids are cholesterol-rich, highly phase-separated, and sensitive to amyloid-induced damage

This study examines lipid composition and amyloid beta interactions in naked mole-rat brain membranes, finding they are cholesterol-rich, highly phase-separated, and more susceptible to amyloid-induced damage compared to mouse membranes.

Developing a Fully-glycosylated Full-length SARS-CoV-2 Spike Protein Model in a Viral Membrane

The paper models and simulates a fully-glycosylated SARS-CoV-2 spike protein in a viral membrane using computational methods and provides the structures for research on COVID-19 prevention and treatment.

RUNX3 regulates cell cycle-dependent chromatin dynamics by functioning as a pioneer factor of the restriction point

This study shows RUNX3 regulates chromatin dynamics at the restriction point by opening and closing target loci through recruitment of chromatin modifiers, influencing cell cycle progression and tumor development.