Repair of leukemia-associated single nucleotide variants via interallelic gene conversion
A. J. Silver, D. J. Brown, S. D. Olmstead, J. M. Watke, A. E. Gorska, L. Tanner, H. E. Ramsey, M. R. Savona
This study demonstrates that CRISPR-mediated interallelic gene conversion can revert heterozygous SNVs in leukemia cells without exogenous templates, improving survival in xenograft models.
bioRxiv · Apr 16, 2024 · PreprintCancer Biology