Author

M. R. Savona

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Assay:bulk RNA-seq· 2 Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Approach:deep learning· 1 Research Focus:differential expression· 1

Frequent Co-Authors

B. N. Smith· 2 shared A. C. Florian· 1 shared B. C. Grieb· 1 shared B. I. Reinfeld· 1 shared B. J. Reisman· 1 shared B. O. Bachmann· 1 shared C. Jones· 1 shared E. M. Reynolds· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersCancer Biology

B. N. Smith

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Cancer BiologybioRxivJul 26, 2023

Ribosome subunit attrition and activation of the p53-MDM4 axis dominate the response of MLL-rearranged cancer cells to WDR5 WIN site inhibition

G. C. Howard, J. Wang, K. L. Rose…·W. P. Tansey

This study identifies that WDR5 WIN site inhibitors suppress ribosome protein gene transcription, induce nucleolar stress, and activate p53 in MLL-rearranged cancer cells, revealing a novel ribosome-directed anti-cancer mechanism.

DOI 10.7554/elife.90683

humanbulk RNA-seq

𝕏 PostBluesky

BiochemistrybioRxivMay 31, 2021

A Family of Glycosylated Macrolides Selectively Target Energetic Vulnerabilities in Leukemia

B. J. Reisman, H. Guo, H. E. Ramsey…·B. O. Bachmann

This study identifies the mitochondrial ATP synthase as the target of apoptolidin family glycomacrolides and demonstrates their efficacy in suppressing leukemia progression.

DOI 10.1038/s41589-021-00900-9

humanproteomics

𝕏 PostBluesky

Cancer BiologybioRxivPreprintJun 5, 2020

MCL1 dependence across MDS subtypes and dual inhibition of MCL1 and BCL2 in MISTRG6 mice

M. A. Fischer, Y. Song, R. Gbyli…·M. R. Savona

The paper assesses MCL1 dependence in MDS subtypes and shows that combined inhibition of BCL2 and MCL1 is synergistic in vitro and reduces MDS engraftment in mice.

DOI 10.1101/2020.06.05.133090

humanmouse

𝕏 PostBluesky