L. Tanner

Biosynthesis of Arcyriaflavin F from Streptomyces venezuelae ATCC 10712

This paper reports a new indolocarbazole biosynthetic pathway in Streptomyces venezuelae and identifies a regioselective C-5 hydroxylating enzyme.

Repair of leukemia-associated single nucleotide variants via interallelic gene conversion

This study demonstrates that CRISPR-mediated interallelic gene conversion can revert heterozygous SNVs in leukemia cells without exogenous templates, improving survival in xenograft models.

OGG1 inhibitor TH5487 alleviates allergic airway inflammation in mice

This study shows that TH5487, an OGG1 inhibitor, reduces allergic airway inflammation in mice by decreasing mucus production, immune cell recruitment, and proinflammatory cytokines.

Zoledronic acid targets the mevalonate pathway causing reduced cell recruitment and attenuation of pulmonary fibrosis

This study shows zoledronic acid reduces pulmonary fibrosis by targeting the mevalonate pathway, decreasing myofibroblast transition and immune cell recruitment in a mouse model.

Small-molecule-mediated OGG1 inhibition attenuates pulmonary inflammation and lung fibrosis

This study shows that the small-molecule OGG1 inhibitor TH5487 reduces fibrosis and inflammation in a mouse model of pulmonary fibrosis.

St. Jude Cloud a Pediatric Cancer Genomic Data Sharing Ecosystem

St. Jude Cloud provides a genomic data sharing ecosystem for pediatric cancer research, offering access to over 10,000 patient genomes and enabling analysis of cancer subtypes and mutational signatures.