The oxygen sensor Prolyl hydroxylase domain 2 regulates the in vivo suppressive capacity of regulatory T cells
Y. Ajouaou, A. Azouz, A. Taquin, S. Denanglaire, H. Hussein, M. Krayem, F. Andris, M. Moser, S. Goriely, O. Leo
This study shows that PHD2 deficiency in regulatory T cells leads to systemic inflammation and impaired control of inflammatory responses, with the PHD2-HIF2 axis playing a key role.
bioRxiv · Mar 23, 2021Immunology