Salmonella cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity
A. Copland, G. M. Mackie, L. Scarfe, D. A. Lecky, N. Gudgeon, R. McQuade, M. Ono, M. Barthel, W.-D. Hardt, H. Ohno, S. Dimeloe, D. Bending, K. M. Maslowski
This study shows that Salmonella-based cancer therapy impairs T cell metabolism, which is linked to its anti-tumor effects.
bioRxiv · Jan 12, 2023 · PreprintImmunology