A. Copland

Lag3 and PD-1 pathways regulate NFAT-dependent TCR signalling programmes during early CD4+ T cell activation

This study shows that PD-1 and Lag3 pathways additively regulate TCR signal duration and NFAT-dependent transcription during early CD4+ T cell activation, with co-blockade enhancing NFAT-dependent gene expression.

Conserved developmental rewiring of the TCR signalosome drives tolerance in innate-like lymphocytes

The paper identifies a conserved mechanism, RePrESS, by which autoreactive innate-like T cells maintain tolerance through rewiring of the TCR signalosome.

Salmonella cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity

This study shows that Salmonella-based cancer therapy impairs T cell metabolism, which is linked to its anti-tumor effects.

Attenuated Salmonella typhimurium cancer therapy has direct effects on the tumor epithelium in colorectal cancer

Attenuated Salmonella typhimurium reduces tumor burden in mice by directly affecting the tumor epithelium through transcriptional and metabolic changes.