Author

G. M. Mackie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

K. M. Maslowski· 3 shared A. Copland· 2 shared H. Ohno· 2 shared A. Angelillo-Scherrer· 1 shared A. Gazdhar· 1 shared A. Tardivel· 1 shared C. Hirzel· 1 shared D. A. Lecky· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersImmunology

K. M. Maslowski

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Author profile →

3 papers

Recent·Most cited

Salmonella cancer therapy metabolically disrupts tumours at the collateral cost of T cell immunity

A. Copland, G. M. Mackie, L. Scarfe, D. A. Lecky, N. Gudgeon, R. McQuade, M. Ono, M. Barthel, W.-D. Hardt, H. Ohno, S. Dimeloe, D. Bending, K. M. Maslowski

This study shows that Salmonella-based cancer therapy impairs T cell metabolism, which is linked to its anti-tumor effects.

bioRxiv · Jan 12, 2023 · PreprintImmunology

LRR protein RNH1 dampens the inflammasome activation and is associated with adverse clinical outcomes in COVID-19 patients

G. Bombaci, M. A. Sarangdhar, N. Andina, A. Tardivel, E. C.-W. Yu, G. M. Mackie, M. Pugh, V. B. Ozan, Y. Banz, T. Spinetti, C. Hirzel, E. Youd, J. C. Schefold, G. S. Taylor, A. Gazdhar, , R. Allam

This study identifies RNH1 as an inhibitor of inflammasome activation, showing its protective role in limiting inflammation and its association with worse outcomes in COVID-19.

bioRxiv · Apr 12, 2021 · PreprintImmunology

Attenuated Salmonella typhimurium cancer therapy has direct effects on the tumor epithelium in colorectal cancer

K. M. Maslowski, M. Takahashi, Y. Sato, G. M. Mackie, I. M. Everard, A. Copland, H. Oda, T. Kanaya, H. Ohno

Attenuated Salmonella typhimurium reduces tumor burden in mice by directly affecting the tumor epithelium through transcriptional and metabolic changes.

bioRxiv · Aug 21, 2019 · PreprintCancer Biology