Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
M. Ratnaparkhe, J. Wong, P.-C. Wei, M. Hlevnjak, T. Kolb, D. Haag, Y. Paul, F. Devens, P. Northcott, D. T. Jones, M. Kool, A. Jauch, A. Pastorczak, W. Mlynarski, A. Korshunov, , A. Ernst
The paper identifies chromothripsis and chromoanasynthesis in tumors with DNA repair deficiencies and links them to MYC/MYCN amplification and therapeutic opportunities.
bioRxiv · May 4, 2018Cancer Biology