Author
T. Kolb
Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
Biology Disciplines
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2018-2023 · peak 3/yrCo-Author Collaboration Network
10 top collaborators · 21 mutual co-author links6 papers
Recent·Most cited
A Novel Interaction Between Aquaporin 1 and Caspase-3 in Pulmonary Arterial Smooth Muscle Cells
S. Niedermeyer, X. Yun, M. Trujillo, M. Andrade, T. Kolb, K. Suresh, M. Damarla, L. Shimoda
The paper identifies a novel interaction between aquaporin-1 and caspase-3 in PASMCs, showing AQP1 levels correlate with caspase-3 activity.
bioRxiv · Oct 5, 2023Cell Biology
MK2 Expression Promotes Non-Small Cell Lung Cancer Cell Death and Predicts Survival
O. Del Rosario, K. Suresh, M. Kallem, G. Singh, A. Shah, Y. Xin, N. Philip, F. D'Alessio, M. Srivastava, A. Bera, L. Shimoda, M. Merchant, M. Rane, C. Machamer, J. Mock, , M. Damarla
This study shows MK2 promotes apoptosis in non-small cell lung cancer by facilitating caspase 3 nuclear translocation, and higher MK2 expression correlates with better patient survival.
bioRxiv · Nov 30, 2021 · PreprintCancer Biology
Single cell multi-omics analysis of chromothriptic medulloblastoma highlights genomic and transcriptomic consequences of genome instability
R. G. Parra, M. J. Przybilla, M. Simovic, H. Susak, M. Ratnaparkhe, J. K. Wong, V. Koerber, P. Mallm, M. Sill, T. Kolb, R. Kumar, N. Casiraghi, D. R. Ghasemi, K. K. Maass, K. W. Pajtler, , A. Ernst
This study analyzes single-cell multi-omics data from medulloblastoma to explore genomic and transcriptomic impacts of chromothripsis and its subclonal variation.
bioRxiv · Jun 25, 2021 · PreprintCancer Biology
A synergistic interaction between HDAC- and PARP inhibitors in childhood tumors with chromothripsis
U. Khalid, M. Simovic, M. Iskar, J. K. L. Wong, R. Kumar, M. Jugold, M. Sill, M. Bolkestein, T. Kolb, M. Hergt, F. Devens, J. Ecker, M. Kool, T. Milde, F. Westermann, , A. Ernst
The paper identifies a synergistic effect between HDAC and PARP inhibitors in childhood tumors with chromothripsis, validated through drug screening and in vivo models.
bioRxiv · Apr 22, 2021Cancer Biology
Defective DNA damage repair leads to frequent catastrophic genomic events in murine and human tumors
M. Ratnaparkhe, J. Wong, P.-C. Wei, M. Hlevnjak, T. Kolb, D. Haag, Y. Paul, F. Devens, P. Northcott, D. T. Jones, M. Kool, A. Jauch, A. Pastorczak, W. Mlynarski, A. Korshunov, , A. Ernst
The paper identifies chromothripsis and chromoanasynthesis in tumors with DNA repair deficiencies and links them to MYC/MYCN amplification and therapeutic opportunities.
bioRxiv · May 4, 2018Cancer Biology