S. E. Stasiak

Stiffening of the Extracellular Matrix is a Sufficient Condition for AirwayHyperreactivity.

This study shows that increasing airway extracellular matrix stiffness through collagen crosslinking leads to enhanced bronchoconstriction, suggesting matrix remodeling as a key driver of airway hyperreactivity in asthma.

Intercellular communication controls agonist-induced calcium oscillations independently of gap junctions in smooth muscle cells.

This study shows that smooth muscle cells communicate via mechanical signaling to modulate calcium waves, independent of gap junctions, leading to altered agonist perception on stiff matrices.