Pparg drives luminal differentiation and luminal tumor formation in the urothelium
T. Tate, T. Xiang, M. Zhou, W. Y. Kim, X. Chen, H. Kim, E. Batourina, C.-S. Lin, C. Lu, S. E. Wobker, J. M. Mckiernan, C. L. Mendelsohn
This study shows that Pparg promotes luminal differentiation and tumor formation in urothelial cells, with tumors showing immune desertion and potential subtype shifts over time.
Nature Communications · Oct 25, 2021Peer-reviewedCancer Biology