Author

C.-S. Lin

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Pathology· 2 Cancer Biology· 1 Cell Biology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:cancer & tumor microenvironment· 3 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Organism:human· 2 Research Focus:development & morphogenesis· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Sanyal· 1 shared A. Yurdagul· 1 shared B. Gerlach· 1 shared C. B. Damoci· 1 shared C. L. Mendelsohn· 1 shared C. Lu· 1 shared C. Z. Zhang· 1 shared C.-H. Wang· 1 shared

Activity by Year

2018-2024 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 7 mutual co-author links

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1 shared paperPathology

A. Sanyal

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Loss of TIM4-Dependent Efferocytosis in Kupffer CellsPromotes Liver Fibrosis in Nonalcoholic Steatohepatitis

H. Shi, X. Wang, B. Gerlach, A. Yurdagul, M. Moore, F. Mirshahi, L. Ronzoni, A. Sanyal, L. Valenti, C.-S. Lin, I. Tabas

This study shows that loss of TIM4 in Kupffer cells impairs efferocytosis of apoptotic hepatocytes in NASH, promoting liver fibrosis, and that restoring TIM4 reduces fibrosis.

bioRxiv · Jan 30, 2024 · PreprintPathology

Abolishing the prelamin A ZMPSTE24 cleavage site leads to progeroid phenotypes with near-normal longevity in mice

Y. Wang, K. Shiladardi, T. Hsu, K. O. Odinammadu, T. Maruyama, W. Wu, C.-S. Lin, C. B. Damoci, E. D. Spear, J.-Y. Shin, W. Hsu, S. Michaelis, H. J. Worman

This study shows that mice with permanently farnesylated prelamin A live nearly normal lifespans but show aging-related defects, suggesting prelamin A accumulation contributes to aging phenotypes.

bioRxiv · Nov 11, 2021Cell Biology

DNA-free CRISPR-Cas9 gene editing of tetraploid tomatoes using protoplast regeneration

C.-T. Hsu, Y.-H. Yuan, P.-X. Zheng, F.-H. Wu, Q.-W. Cheng, Y.-L. Wu, S. Lin, J.-J. Yue, Y.-H. Cheng, S.-I. L. Lin, M.-C. Shih, J. Sheen, Y.-C. Lin, C.-S. Lin

DNA-free CRISPR-Cas9 editing in wild tomatoes generates stable, inheritable diploid and tetraploid regenerants without chromosomal changes or off-target effects.

bioRxiv · Nov 2, 2021 · PreprintPlant Biology

Pparg drives luminal differentiation and luminal tumor formation in the urothelium

T. Tate, T. Xiang, M. Zhou, W. Y. Kim, X. Chen, H. Kim, E. Batourina, C.-S. Lin, C. Lu, S. E. Wobker, J. M. Mckiernan, C. L. Mendelsohn

This study shows that Pparg promotes luminal differentiation and tumor formation in urothelial cells, with tumors showing immune desertion and potential subtype shifts over time.

Nature Communications · Oct 25, 2021Peer-reviewedCancer Biology

A GYS2/p53 negative feedback loop restricts tumor growth in HBV-related hepatocellular carcinoma

S.-L. Chen, C. Z. Zhang, L.-L. Liu, S.-X. Lu, Y.-H. Pan, C.-H. Wang, Y.-F. He, C.-S. Lin, X. Yang, D. Xie, J.-P. Yun

This paper identifies a GYS2/p53 negative feedback loop that suppresses tumor growth in HBV-related hepatocellular carcinoma by regulating glycogen metabolism and p53 activity.

bioRxiv · Jul 20, 2018Pathology