RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell functionality
H. Ibrahim, D. Balboa, J. Saarimäki-Vire, H. Montaser, O. Dyachok, P.-E. Lund, M. Omar-Hmeadi, J. Kvist, O. P. Dwivedi, V. Lithovius, T. Barsby, V. Chandra, S. Eurola, J. Ustinov, T. Tuomi, , T. Otonkoski
This study shows that RFX6 haploinsufficiency impairs beta cell function, leading to reduced insulin secretion and increased diabetes risk.
bioRxiv · Nov 15, 2023 · PreprintCell Biology