Author

T. Otonkoski

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Bioengineering· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 4 Organism:human· 4 Approach:experimental assay· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

D. Balboa· 3 shared H. Montaser· 3 shared E.-M. Jouhilahti· 2 shared H. Ibrahim· 2 shared J. Kere· 2 shared J. Saarimäki-Vire· 2 shared J. Weltner· 2 shared R. Trokovic· 2 shared

Activity by Year

2017-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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3 shared papersCell Biology

D. Balboa

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Quantifying stem cell derived islet graft volume and composition with FDOPA positron emission tomography

V. Lithovius, S. Lahdenpohja, H. Ibrahim, J. Saarimäki-Vire, L. Uusitalo, H. Montaser, K. Mikkola, C.-B. Yim, T. Keller, J. Rajander, D. Balboa, T. Barsby, O. Solin, P. Nuutila, T. J. Grönroos, T. Otonkoski

This study uses PET tracers to noninvasively monitor stem cell-derived islet graft volume and composition in mice, showing strong correlation with actual graft size and beta cell proportion.

bioRxiv · Dec 18, 2023Cell Biology

RFX6 haploinsufficiency predisposes to diabetes through impaired beta cell functionality

H. Ibrahim, D. Balboa, J. Saarimäki-Vire, H. Montaser, O. Dyachok, P.-E. Lund, M. Omar-Hmeadi, J. Kvist, O. P. Dwivedi, V. Lithovius, T. Barsby, V. Chandra, S. Eurola, J. Ustinov, T. Tuomi, , T. Otonkoski

This study shows that RFX6 haploinsufficiency impairs beta cell function, leading to reduced insulin secretion and increased diabetes risk.

bioRxiv · Nov 15, 2023 · PreprintCell Biology

Thymidylate synthase disruption to limit cell proliferation in cell therapies

R. Sartori-Maldonado, H. Montaser, I. Soppa, S. Eurola, M. Balaz, H. Puttonen, T. Otonkoski, J. Saarimaki-Vire, K. Wartiovaara

This study disrupts thymidylate synthase to control cell proliferation in cell therapies without affecting cell function.

bioRxiv · Jun 26, 2023Bioengineering

Transient DUX4 expression induces blastomere-like expression program that is marked by SLC34A2

M. Yoshihara, I. Kirjanov, S. Nykänen, J. Sokka, J. Weltner, K. Lundin, L. Gawriyski, E.-M. Jouhilahti, M. Varjosalo, M. H. Tervaniemi, T. Otonkoski, R. Trokovic, S. Katayama, S. Vuoristo, J. Kere

The paper shows that transient DUX4 expression in hESCs generates iBM cells with EGA-like profiles, resembling 8-cell blastomeres and can be enriched using SLC34A2.

bioRxiv · Aug 25, 2021Cell Biology

Human pluripotent reprogramming with CRISPR activators

J. Weltner, D. Balboa, S. Katayama, M. M. Bespalov, K. Krjutskov, E.-M. Jouhilahti, R. Trokovic, J. Kere, T. Otonkoski

This study reprograms human skin fibroblasts into iPSC using CRISPRa, showing that targeting an Alu-motif enhances reprogramming efficiency by improving activation of NANOG and REX1.

bioRxiv · Oct 19, 2017Cell Biology