ImmunologybioRxiv
A Polymorphic Residue That Attenuates the Antiviral Potential of Interferon Lambda 4 in Hominid Lineages
C. G. G. Bamford, E. Aranday-Cortes, I. Cordeiro Filipe…·J. McLauchlan
The paper identifies a polymorphic residue in IFN{lambda}4 that reduces its antiviral activity in humans compared to other hominids, contributing to differences in HCV clearance.
DOI 10.1371/journal.ppat.1007307