Machine learning guided association of adverse drug reactions with in vitro target-based pharmacology
R. Ietswaart, S. Arat, A. X. Chen, S. Farahmand, B. Kim, W. DuMouchel, D. Armstrong, A. Fekete, J. J. Sutherland, L. Urban
The paper uses machine learning to link drug targets with adverse drug reactions using in vitro pharmacology data and FDA reports, identifying 221 target-ADR associations.
bioRxiv · Mar 12, 2020Pharmacology & Toxicology