L. Urban

A novel preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs

The paper introduces a database of drug-target-adverse reaction associations using in vitro assays, revealing novel off-target activities and challenging existing ADR links.

Capturing species-wide diversity of the gut microbiota and its relationship with genomic variation in the critically endangered kakapo

This study analyzes the gut microbiota of kakapos to assess its relationship with host genomic diversity and identifies sex as a significant factor influencing microbiota diversity.

Commonly used Hardy-Weinberg equilibrium filtering schemes impact population structure inferences using RADseq data

The paper shows that common Hardy-Weinberg equilibrium filtering in RADseq data affects population structure inferences and recommends best practices for its implementation.

Phospholipidosis is a shared mechanism underlying the in vitro antiviral activity of many repurposed drugs against SARS-CoV-2

Machine learning guided association of adverse drug reactions with in vitro target-based pharmacology

The paper uses machine learning to link drug targets with adverse drug reactions using in vitro pharmacology data and FDA reports, identifying 221 target-ADR associations.

Freshwater monitoring by nanopore sequencing

This paper presents a cost-effective nanopore sequencing workflow for freshwater monitoring, showing it can track microbiomes and detect pathogens with species-level resolution.

The Importance of Reverse Translation for Preclinical Off-Target Mitigation: Quantification and Mitigation of Biases in the FDA Adverse Event Reporting System

This paper quantifies and mitigates biases in the FDA Adverse Event Reporting System (FAERS) by mapping drug identifiers to chemical structures, revealing underlying molecular mechanisms of adverse drug reactions.