Author

D. Armstrong

Primary ORCID profile (0009-0006-5873-4332 · 1 paper)Unclaimed ORCID profile · follow to get notified of new preprints

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D. ArmstrongiD1 paper · University of Nebraska–Lincoln

Biology Disciplines

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Biochemistry· 1 Bioengineering· 1 Evolutionary Biology· 1 Immunology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:drug response / drug discovery· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

B. L. Hodges· 2 shared G. L. Austin· 2 shared J. R. Pauly· 2 shared A. Bullivant· 1 shared A. Carisey· 1 shared A. DePaoli-Roach· 1 shared A. Fekete· 1 shared A. Rodriguez-Verdugo· 1 shared

Activity by Year

2019-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersBiochemistry

B. L. Hodges

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

MAGE-A4-Responsive Plasma Cells Promote Non-Small Cell Lung Cancer

D. Armstrong, C.-Y. Chang, M. J. Hong, L. K. Green, W. Hudson, Y. Shen, L.-Z. Song, S. Jammi, B. Casal, C. J. Creighton, A. Carisey, X. Zhang, N. McKenna, S. Kang, H.-S. Lee, , F. Kheradmand

The paper shows MAGE-A4 promotes NSCLC by recruiting IgA+ plasma cells, reducing tumor burden and enhancing T cell activity.

bioRxiv · Jul 10, 2024 · PreprintImmunology

Evolution Under Thermal Stress Affects Escherichia colis Resistance to Antibiotics

A. Bullivant, N. Lozano-Huntelman, K. Tabibian, V. Leung, D. Armstrong, H. Dudley, V. M. Savage, A. Rodriguez-Verdugo, P. Yeh

This study examines how thermal stress evolution affects antibiotic resistance in Escherichia coli, finding decreased optimal growth temperature and complex resistance patterns.

bioRxiv · Feb 27, 2024 · PreprintEvolutionary Biology

Machine learning guided association of adverse drug reactions with in vitro target-based pharmacology

R. Ietswaart, S. Arat, A. X. Chen, S. Farahmand, B. Kim, W. DuMouchel, D. Armstrong, A. Fekete, J. J. Sutherland, L. Urban

The paper uses machine learning to link drug targets with adverse drug reactions using in vitro pharmacology data and FDA reports, identifying 221 target-ADR associations.

bioRxiv · Mar 12, 2020Pharmacology & Toxicology

Targeting pathogenic Lafora bodies in Lafora disease using an antibody-enzyme fusion

M. K. Brewer, A. Uittenbogaard, G. L. Austin, J. J. McCarthy, D. M. Segvich, A. DePaoli-Roach, P. J. Roach, B. L. Hodges, J. Zeller, J. R. Pauly, T. McKnight, D. Armstrong, M. Gentry

This paper develops an antibody-enzyme fusion that degrades Lafora bodies in a mouse model of Lafora disease, reducing LB load and showing therapeutic potential.

bioRxiv · Jun 21, 2019Biochemistry

Central Nervous System Delivery and Biodistribution Analysis of an Antibody-Enzyme Fusion for the Treatment of Lafora Disease

G. L. Austin, Z. R. Simmons, J. E. Klier, B. L. Hodges, R. Shaffer, T. R. McKnight, J. R. Pauly, D. Armstrong, C. W. Vander Kooi, M. S. Gentry

This study evaluates the cerebral delivery and biodistribution of VAL-0417, an antibody-enzyme fusion for Lafora disease, showing intracerebroventricular administration is most effective.

bioRxiv · Jun 14, 2019Bioengineering