Author

J. J. Sutherland

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Pharmacology & Toxicology· 4

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Approach:statistical model· 2 Approach:deep learning· 1

Frequent Co-Authors

A. Fekete· 2 shared B. van de Water· 2 shared G. Callegaro· 2 shared J. L. Stevens· 2 shared J. Saez-Rodriguez· 2 shared L. Urban· 2 shared P. Trairatphisan· 2 shared S. J. Kunnen· 2 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersPharmacology & Toxicology

A. Fekete

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4 papers

Recent·Most cited

Utilizing gene co-expression networks with the rat kidney TXG-MAPr tool to enhance safety assessment, biomarker identification and human translation

S. J. Kunnen, G. Callegaro, J. J. Sutherland, P. Trairatphisan, H. van Kessel, L. S. Wijaya, G. Chung, K. Pye, K. M. Goldstein, C. R. Teague, C. P. Fisher, J. Saez-Rodriguez, C. Brown, S. A. Elmore, K. M. Heinz-Taheny, , B. van de Water

This study builds gene co-expression networks from rat kidney toxicogenomics data and integrates them into a web tool to improve safety assessment and biomarker identification for drug development.

bioRxiv · Nov 3, 2023 · PreprintPharmacology & Toxicology

A novel preclinical secondary pharmacology resource illuminates target-adverse drug reaction associations of marketed drugs

J. J. Sutherland, D. Yonchev, A. Fekete, L. Urban

The paper introduces a database of drug-target-adverse reaction associations using in vitro assays, revealing novel off-target activities and challenging existing ADR links.

bioRxiv · Jan 31, 2023Pharmacology & Toxicology

The human hepatocyte TXG-MAPr: WGCNA transcriptomic modules to support mechanism-based risk assessment

G. Callegaro, S. J. Kunnen, P. Trairatphisan, S. Grosdidier, M. Niemeijer, W. den Hollander, E. Guney, J. P. Gonzalez, L. Furlong, Y. W. Webster, J. Saez-Rodriguez, J. J. Sutherland, J. Mollon, J. L. Stevens, B. van de Water

The paper introduces TXG-MAPr, a tool for analyzing toxicogenomic data using WGCNA to identify stress response modules across species and platforms.

Archives of Toxicology · Oct 9, 2021Peer-reviewedPharmacology & Toxicology

Machine learning guided association of adverse drug reactions with in vitro target-based pharmacology

R. Ietswaart, S. Arat, A. X. Chen, S. Farahmand, B. Kim, W. DuMouchel, D. Armstrong, A. Fekete, J. J. Sutherland, L. Urban

The paper uses machine learning to link drug targets with adverse drug reactions using in vitro pharmacology data and FDA reports, identifying 221 target-ADR associations.

bioRxiv · Mar 12, 2020Pharmacology & Toxicology