Assessment of pre-clinical liver models based on their ability to predict the liver-tropism of AAV vectors
A. Westhaus, M. Cabanes-Creus, K. L. Dilworth, E. Zhu, D. Salas Gomez, R. G. Navarro, A. K. Amaya, S. Scott, M. Kwiatek, A. L. McCorkindale, T. E. Hayman, S. Frahm, D. P. Perocheau, B. M. Tran, E. Vincan, , L. Lisowski
This study evaluates six AAV vectors in twelve preclinical liver models to identify the most predictive for AAV capsid selection in human hepatocyte transgene delivery.
bioRxiv · Sep 28, 2022 · PreprintBioengineering