Author

A. J. Thrasher

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 2 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 4 Research Focus:cell type annotation· 3 Assay:ATAC-seq· 2 Assay:bulk RNA-seq· 2 Research Focus:gene regulatory network inference· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

A. Cavazza· 2 shared G. Santilli· 2 shared R. Rai· 2 shared A. K. Amaya· 1 shared A. L. McCorkindale· 1 shared A. Naseem· 1 shared A. Westhaus· 1 shared A. Worth· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersBioengineering

A. Cavazza

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Assessment of pre-clinical liver models based on their ability to predict the liver-tropism of AAV vectors

A. Westhaus, M. Cabanes-Creus, K. L. Dilworth, E. Zhu, D. Salas Gomez, R. G. Navarro, A. K. Amaya, S. Scott, M. Kwiatek, A. L. McCorkindale, T. E. Hayman, S. Frahm, D. P. Perocheau, B. M. Tran, E. Vincan, , L. Lisowski

This study evaluates six AAV vectors in twelve preclinical liver models to identify the most predictive for AAV capsid selection in human hepatocyte transgene delivery.

bioRxiv · Sep 28, 2022 · PreprintBioengineering

Single Nucleus Sequencing of Human Colon Visceral Smooth Muscle Cells, PDGFRα Cells, and Interstitial Cells of Cajal

S. Schneider, S. K. Hashmi, A. J. Thrasher, D. R. Kothakapa, C. M. Wright, R. O. Heuckeroth

The paper performs single-nucleus RNA sequencing on human colon SIP syncytium cells to identify novel features and gene expression differences across cell types and bowel regions.

bioRxiv · Apr 14, 2022 · PreprintCell Biology

Optimized cell culture conditions promote ex-vivo manipulation and expansion of primitive hematopoietic stem cells for therapeutic gene editing.

R. Rai, W. Vetharoy, A. Naseem, Z. Steinberg, A. J. Thrasher, G. Santilli, A. Cavazza

This study optimizes ex-vivo culture conditions to enhance gene editing efficiency in primitive hematopoietic stem cells while preserving their stemness and enabling expansion.

bioRxiv · Jan 11, 2022 · PreprintBioengineering

Wiskott Aldrich syndrome protein regulates non-selective autophagy and mitochondrial homeostasis in human myeloid cells

E. Rivers, R. Rai, J. Lotscher, M. Hollinshead, G. Markelj, J. Thaventheran, A. Worth, A. Cavazza, C. Hess, M. Bajaj-Elliott, A. J. Thrasher

This study shows that WASp deficiency impairs autophagy and mitochondrial function in human myeloid cells, with ARP2/3 dependency and metabolic consequences.

bioRxiv · Feb 6, 2020Physiology