Maximizing the Anti-tumor Potential of Immune Checkpoint Blockade through Modulation of Myeloid-specific CXCL16 and STAT1 Signaling
B. Palakurthi, I. H. Guldner, X. Liu, A. K. Martino, Q. Wang, S. Fross, R. A. Neff, S. M. Golomb, E. Howe, S. Zhang
This study shows that modulating STAT1 signaling in chemotherapy-primed breast cancer enhances anti-PD-1 immunotherapy efficacy by altering myeloid cell dynamics.
bioRxiv · Mar 28, 2022 · PreprintCancer Biology