Author

I. H. Guldner

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Immunology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:statistical model· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Approach:deep learning· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2

Frequent Co-Authors

S. Zhang· 4 shared B. Palakurthi· 2 shared Q. Wang· 2 shared S. M. Golomb· 2 shared A. D. Panopoulos· 1 shared A. E. Yamasaki· 1 shared A. K. Martino· 1 shared A. T. Specht· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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4 shared papersCancer Biology

S. Zhang

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Author profile →

4 papers

Recent·Most cited

Maximizing the Anti-tumor Potential of Immune Checkpoint Blockade through Modulation of Myeloid-specific CXCL16 and STAT1 Signaling

B. Palakurthi, I. H. Guldner, X. Liu, A. K. Martino, Q. Wang, S. Fross, R. A. Neff, S. M. Golomb, E. Howe, S. Zhang

This study shows that modulating STAT1 signaling in chemotherapy-primed breast cancer enhances anti-PD-1 immunotherapy efficacy by altering myeloid cell dynamics.

bioRxiv · Mar 28, 2022 · PreprintCancer Biology

Multi-modal single cell analysis reveals brain immune landscape plasticity during aging and gut microbiota dysbiosis

S. M. Golomb, I. H. Guldner, A. Zhao, Q. Wang, B. Palakurthi, J. Lopez, K. Yang, S. Zhang

This study uses CITE-seq to analyze brain immune cell plasticity in aged mice with and without gut dysbiosis, revealing transcriptional shifts in monocytes and ILCs linked to neuroinflammation.

bioRxiv · Jul 15, 2020Immunology

GRP78 promotes stemness in normal and neoplastic cells

C. Conner, T. W. Lager, I. H. Guldner, M.-Z. Wu, Y. Hishida, T. Hishida, S. Ruiz, A. E. Yamasaki, R. C. Gilson, J. C. Izpisua Belmonte, P. C. Gray, J. A. Kelber, S. Zhang, A. D. Panopoulos

This study identifies GRP78 as a marker of stem-like properties in breast cancer cells, showing its role in promoting stemness and metastatic potential.

Scientific Reports · Feb 26, 2020Peer-reviewedCancer Biology

Rab11b-mediated integrin recycling promotes brain metastatic adaptation and outgrowth

E. N. Howe, M. D. Burnette, M. E. Justice, J. W. Clancy, I. H. Guldner, P. M. Schnepp, V. Hendrick, U. K. Aryal, A. T. Specht, J. Li, C. D'Souza-Schorey, J. J. Zartman, S. Zhang

This study identifies Rab11b as a mediator of breast cancer brain metastasis by promoting integrin recycling and mechanotransduction.

bioRxiv · Jun 11, 2019Cancer Biology