Author

S. Herzon

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Assay:DNA methylation· 1 Organism:human· 1

Frequent Co-Authors

M. Xue· 2 shared A. R. Healy· 1 shared E. E. Shine· 1 shared J. M. Crawford· 1 shared J. R. Patel· 1 shared K. Wernke· 1 shared Y. V. Surovtseva· 1 shared

Activity by Year

2018-2019 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 16 mutual co-author links

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2 shared papersMicrobiology

M. Xue

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Depurination of colibactin-derived interstrand cross-links.

M. Xue, K. Wernke, S. Herzon

This study shows colibactin-derived interstrand cross-links (ICLs) can evolve into DNA double-strand breaks (DSBs) through depurination and phosphate elimination, leading to nicked single-strand breaks and DSBs.

bioRxiv · Dec 10, 2019Microbiology

Model colibactins exhibit human cell genotoxicity in the absence of host bacteria

E. E. Shine, M. Xue, J. R. Patel, A. R. Healy, Y. V. Surovtseva, S. Herzon, J. M. Crawford

This study shows that free model colibactins induce DNA double-strand breaks in human cells without requiring host bacteria, revealing mechanisms of genotoxicity and product diversification in colibactin biosynthesis.

bioRxiv · Sep 29, 2018Cancer Biology