PhysiologyCirculationPeer-reviewed
Mouse Model of Heart Attack and Stroke Shows Improved Survival with MPO Inhibition
S. Shamsuzzaman, R. A. Deaton, H. Doviak…·G. K. Owens
The paper introduces a mouse model of advanced atherosclerosis that exhibits spontaneous plaque rupture leading to MI or stroke, and shows that MPO inhibition with AZM198 reduces mortality and plaque rupture incidence.
DOI 10.1161/circulationaha.123.067931