Author

R. A. Deaton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

G. F. Alencar· 2 shared G. K. Owens· 2 shared L. S. Shankman· 2 shared S. Karnewar· 2 shared A. Salamon· 1 shared B. Kull· 1 shared C. Williams· 1 shared E. Benavente· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersPhysiology

G. F. Alencar

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2 papers

Recent·Most cited

Mouse Model of Heart Attack and Stroke Shows Improved Survival with MPO Inhibition

S. Shamsuzzaman, R. A. Deaton, H. Doviak, M. Evans, A. Salamon, S. Karnewar, V. Serbulea, G. F. Alencar, L. S. Shankman, K. Walsh, S. Bekiranov, O. Kocher, M. Kreiger, B. Kull, M. Persson, , G. K. Owens

The paper introduces a mouse model of advanced atherosclerosis that exhibits spontaneous plaque rupture leading to MI or stroke, and shows that MPO inhibition with AZM198 reduces mortality and plaque rupture incidence.

Circulation · Aug 27, 2024Peer-reviewedPhysiology

IL-1β inhibition partially negates the beneficial effects of diet-induced lipid lowering

S. Karnewar, V. KARNEWAR, R. A. Deaton, L. S. Shankman, E. Benavente, C. Williams, X. Bradley, G. F. Alencar, G. Bulut, S. Kirmani, R. Baylis, E. Zunder, H. H. den Ruijter, G. Pasterkamp, G. K. Owens

This study shows that inhibiting IL-1β in mice reduces the beneficial effects of diet-induced lipid lowering on atherosclerosis, increasing plaque burden and decreasing plaque stability.

bioRxiv · Oct 13, 2023 · PreprintCell Biology