K. Walsh

Mouse Model of Heart Attack and Stroke Shows Improved Survival with MPO Inhibition

The paper introduces a mouse model of advanced atherosclerosis that exhibits spontaneous plaque rupture leading to MI or stroke, and shows that MPO inhibition with AZM198 reduces mortality and plaque rupture incidence.

Long-term NMN treatment increases lifespan and healthspan in mice in a sex dependent manner

This study shows that long-term NMN treatment improves healthspan and extends lifespan in female mice but not males, with sex-specific effects on metabolism and microbiome.

Modelling the gut microbiota of children with malnutrition: in vitro models reveal differences in fermentability of widely consumed carbohydrates

This study uses an in vitro model to show that inulin is poorly fermented by the gut microbiota of children with severe acute malnutrition, while legume-based feeds and milk oligosaccharides are more effectively fermented.

Giardia Antagonizes Beneficial Functions of Indigenous and Therapeutic Intestinal Bacteria during Malnutrition

This study shows Giardia reduces the beneficial effects of Lactobacillus in malnourished mice, altering microbial balance and increasing intestinal damage.

Glioblastoma and other intracranial tumors elicit systemic sympathetic hyperactivity that limits immunotherapeutic responses

This study shows that intracranial tumors cause systemic sympathetic hyperactivity, impairing T cell function and limiting immunotherapy, and that beta-adrenergic blockade improves outcomes in mouse models and human patients.

The Cell Surface Receptors Ror1/2 Control Cardiac Myofibroblast Differentiation

This study shows that Ror1/2 receptors are essential for cardiac myofibroblast differentiation and heart remodeling in response to pressure overload.