Author

S. Hilfiker

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

B. Brahmia· 1 shared B. Fernandez· 1 shared E. Fdez· 1 shared E. J. Kennedy· 1 shared K. Alexander· 1 shared M. Romo-Lozano· 1 shared P. Rivero-Rios· 1 shared R. Fasiczka· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperBiochemistry

B. Brahmia

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Author profile →

2 papers

Recent·Most cited

Targeting phosphoRab-RILPL Interactions as a Strategy to Downregulate Pathogenic LRRK2 in Parkinson's Disease

K. Alexander, Y. Naaldijk, R. Fasiczka, B. Brahmia, T. Chen, S. Hilfiker, E. J. Kennedy

This paper demonstrates that constrained peptides mimicking phosphorylated Rab8 can block RILPL interactions and restore ciliogenesis and centrosomal cohesion defects in cells with mutant LRRK2.

bioRxiv · Nov 6, 2023Biochemistry

Distinct roles for RAB10 and RAB29 in pathogenic LRRK2-mediated endolysosomal trafficking alterations

P. Rivero-Rios, M. Romo-Lozano, B. Fernandez, E. Fdez, S. Hilfiker

This study investigates how mutations in LRRK2 affect RAB proteins involved in endolysosomal trafficking and shows that RAB10 and RAB29 have distinct roles in mitigating these effects.

bioRxiv · Jun 20, 2020Cell Biology