Alzheimer’s Amyloid-Beta Intermediates Generated by Polymer-Nanodiscs
B. Sahoo, T. Genjo, M. Bekier, S. J. Cox, A. Stoddard, M. Ivanova, K. Yasuhara, C. A. Fierke, Y. Wang, A. Ramamoorthy
This study uses PMA-nanodiscs to study Aβ1-40 aggregation, showing they trap intermediates and reduce neurotoxicity of oligomers.
bioRxiv · Oct 5, 2018Biophysics